Protein function
Encodes a Dicer homolog involved in microRNA processing.
Phenotype
Single mutant: DCL1 downregulation through a weak allele (
sin1-1 ; Ler background) leads to late flowering under both SD and LD conditions. (
dcl1 null mutation is lethal.)
[Ray et al., 1996] Remarks: dcl1 single mutant shows lower microRNA expression levels, and this phenotype is enhanced in both
dcl1;
dcl3 and
dcl1;
dcl4 double mutants.
[Gasciolli et al., 2005] Multiple mutant:The
dcl1;
dcl3 double mutant is late flowering under both SD and LD. (The late flowering time is suppresed by vernalization in the Col
FRI background.)
[Schmitz et al., 2007] Function:Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions