Detailed gene information

Genes [306]

TAIR: AT1G01040


Ray A et al., 1996, Development
Schauer S E et al., 2002, Trends Plant Sci.
Xie Z et al., 2003, Curr. Biol.
Kurihara Y et al., 2004, Proc. Natl. Acad. Sci. U.S.A.
Gasciolli V et al., 2005, Curr. Biol.
Schmitz R J et al., 2007, Genetics
Tsuzuki M et al., 2014, RNA

Appears in the following schemes

microRNA biosynthesis
General processes & autonomous pathway

Protein function

Encodes a Dicer homolog involved in microRNA processing.


Single mutant:
DCL1 downregulation through a weak allele (sin1-1 ; Ler background) leads to late flowering under both SD and LD conditions. ( dcl1 null mutation is lethal.) [Ray et al., 1996]

dcl1 single mutant shows lower microRNA expression levels, and this phenotype is enhanced in both dcl1;dcl3 and dcl1;dcl4 double mutants. [Gasciolli et al., 2005]

Multiple mutant:
The dcl1;dcl3 double mutant is late flowering under both SD and LD. (The late flowering time is suppresed by vernalization in the Col FRI background.) [Schmitz et al., 2007]

Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3. [Data from UniProt]

Regulators, targets and interactors

Downstream actors

Upstream actors

Protein-protein interactions

DCL1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins