Detailed gene information

Genes [306]

TAIR: AT1G09700


Lu C et al., 2000, Plant Cell
Vazquez F et al., 2004, Curr. Biol.
Han M et al., 2004, Proc. Natl. Acad. Sci. U.S.A.
Dong Z et al., 2008, Proc. Natl. Acad. Sci. U.S.A.
Laubinger S et al., 2008, Proc. Natl. Acad. Sci. U.S.A.
Li S et al., 2012, J. Exp. Bot.

Appears in the following schemes

microRNA biosynthesis

Protein function

Encodes a RNA-binding protein involved in microRNA biogenesis.


Single mutant:
hst1 single mutant shows some morphological defects, including precocious transition from the juvenile to the adult phase and early flowering under SD conditions.( No data under LD condititions. hst1 single mutant has pleiotropic defects. The flowering-time phenotype of the single mutant is likely due to the precocious transitions from the juvenile to the adult phase.) [Lu et al., 2000][Vazquez et al., 2004]

Multiple mutant:
hyl1;hen1 double mutant is unable to complete a full life cycle. [Vazquez et al., 2004]

Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing. [Data from UniProt]

Regulators, targets and interactors

Downstream actors

Upstream actors

Protein-protein interactions

HYL1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins