Protein function
Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
Phenotype
Overexpressor: PFT1 overexpressor is early flowering under SD conditions only.
[Cerdü¾Œ–”¼n et al., 2003] Single mutant: pft1 single mutant is late flowering under both SD and LD conditions.
[Cerdü¾Œ–”¼n et al., 2003][Kidd et al., 2009][Iü¾Œ–˜¼igo et al., 2012][Elfving et al., 2011][Wollenberg et al., 2008] Remarks: Increasing the nuclear concentration of PFT1 protein through a GR-DEX treatment leads to early flowering under LD conditions.
[Iü¾Œ–˜¼igo et al., 2012] Remarks: The modification of
PFT1 Short Tandem Repeat (STR) length converts PFT1 into a floral repressor.
[Rival et al., 2014] Function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Positive regulator of shade avoidance and of jasmonate signaling. Acts in repression of PhyB-mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FT --
[Cerdn et al., 2003][Kidd et al., 2009][Iigo et al., 2012] --
[View TAIR record]CO --
[Cerdn et al., 2003][Wollenberg et al., 2008][Iigo et al., 2012] --
[View TAIR record] Upstream actors
causality PHYB --
[Cerdn et al., 2003] --
[View TAIR record] Protein-protein interactions