Protein function
Encodes a component of an E3 protein ligase complex.
Phenotype
RNA interference: RNAi downregulation of
CUL3A expression partially impairs the response to vernalization in the Col
FRI background under LD conditions. ( No data under SD conditions.)
[Hu et al., 2014] Multiple mutant: The
cul3a;
cul3b multiple hypomorphic mutant is late flowering under LD conditions. (No data under SD conditions.)
[Thomann et al., 2009] Function:Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. Functions in distal root patterning, by an ethylene-independent mechanism. Functionally redundant with CUL3B.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FRI --
[Hu et al., 2014] --
[View TAIR record] Upstream actors
causality WRKY34, MSP3 --
[Hu et al., 2014] --
[View TAIR record] Protein-protein interactions
FRI --
[Christians et al., 2012] --
[View TAIR record]