Detailed gene information

Genes [306]




RRP6L1
AtRRP6L1
TAIR: AT1G54440
UNIPROT: Q0WVE8
NOWOMICS: View List

Publications

Lange H et al., 2008, Mol. Cell. Biol.
Zhang H et al., 2014, Mol. Cell
Shin J et al., 2014, PLoS Genet.
Hsu Y et al., 2014, Mol Plant

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes a putative exoribonuclease H.

Phenotype

Single mutant:
rrp6l1 single mutant is very slightly late flowering under LD conditions. ( No data under SD conditions.). [Shin et al., 2014]

Multiple mutant:
rrp6l1;rrp6l2 multiple mutant is late flowering under both SD and LD conditions. [Shin et al., 2014]

Remarks:
rrp6l1;rrp6l2 multiple mutant has increased FLC expression levels. [Shin et al., 2014]

Function:
Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed:23555312, PubMed:24726328, PubMed:24719467, PubMed:25211139). Involved in transcriptional gene silencing (TGS). Plays a role for DNA methylation in the RNA-directed DNA methylation (RdDM) pathway. Contributes to the methylation status of the retrotransposon SN1. Required for DNA methylation only at a subset of RdDM target loci (PubMed:24719467). Plays a regulatory role in RdDM through retention of non-coding RNAs (ncRNAs) in normal cells. Helps to retain Pol V-transcribed RNAs in chromatin to enable their scaffold function and is required for genome-wide Pol IV-dependent siRNA (24 nt siRNA) production that may involve retention of Pol IV transcripts (PubMed:24726328). Involved in association with RRP6L2 in the silencing of the solo LTR locus. Controls levels of ncRNAs from the solo LTR locus. Seems to function independently of the RdDM pathway (PubMed:23555312). Functions redundantly with RRP6L2 in the regulation of FLC locus. Participates in the maintenance of trimethylated Lys-27 (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus (PubMed:25211139). Seems not involved in the exosomal RNA degradation (PubMed:24726328, PubMed:25211139). Can complement the growth defect of a yeast mutant lacking RRP6 exonuclease (PubMed:18285452). [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


RRP6L1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins