Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
Single mutant: med13
single mutant is late flowering under LD conditions only. [Gillmor et al., 2014][Imura et al., 2012] Remarks: med13
single mutant shows increased FLC
expression levels. [Gillmor et al., 2014] Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts closely together with MAB12. Involved in the regulation of embryo patterning and cotyledon organogenesis. May act through transient repression of specific genes such as the ones responsive to auxin. [Data from UniProt]
Regulators, targets and interactors