Detailed gene information

Genes [306]




VIM1, ORTH2
VARIANT IN METHYLATION 1, ORTHRUS 2
TAIR: AT1G57820
UNIPROT: Q8VYZ0
NOWOMICS: View List

Publications

Woo H R et al., 2007, Genes Dev.
Woo H R et al., 2008, PLoS Genet.
Kim J et al., 2014, Mol Plant
Shook M S et al., 2014, Epigenetics

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes an E3 ubiquitin ligase.

Phenotype

Remarks:
VIM1 overexpressor has reduced root growth. [Kraft et al., 2008]

Single mutant:
vim1 single mutant does not display any flowering-time phenotype. [Woo et al., 2008]

Remarks:
vim1;vim2;vim3 multiple mutant shows increased FWA expression levels. [Woo et al., 2008]

Multiple mutant:
vim1;vim2;vim3 triple mutant is late flowering under LD conditions. ( No data available under SD conditions.) [Woo et al., 2008]

Remarks:
Strangely, both vim1;vim2;vim3 multiple mutant and VIM1 overexpressor are late flowering, suggesting that those phenotypes are caused by different mechanisms. [Woo et al., 2008]

Function:
E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin. [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


VIM1, ORTH2 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins