Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Nelson D C et al., 2000, Cell
Imaizumi T et al., 2003, Nature
Imaizumi T et al., 2005, Science
Sawa M et al., 2007, Science
Baudry A et al., 2010, Plant Cell
Song Y H et al., 2012, Science
Song Y H et al., 2014, Proc. Natl. Acad. Sci. U.S.A.

Appears in the following schemes

Circadian clock overview
Photoperiod pathway
Time-course regulation of photoperiodic pathway

Protein function

Encodes a flavin-binding kelch repeat F box protein that is part of a E3 ubiquitin ligase complex.

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Phenotype

Overexpressor:
FKF1 overexpressor does not display any flowering-time phenotype. [Sawa et al., 2007]

Single mutant:
fkf1 single mutant is late flowering under LD conditions only. [Fornara et al., 2009][Imaizumi et al., 2005][Song et al., 2012][Nelson et al., 2000]

Remarks:
FKF1 protein binds to CONSTANS and stabilize it during LD afternoon. FKF1 also interacts with GI. [Song et al., 2014]

Remarks:
Overexpression of GI partially supresses the flowering-time phenotype of the fkf1 single mutant. [Fornara et al., 2009]

Function:
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO3) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. Forms a complex with GIGANTEA (GI) to regulates CONSTANS (CO) expression. Promotes CO expression during the light period of long days by decreasing the stability of CDF1 and CDF2 and by interacting directly with the CO protein and stabilizing it. ADO3 function is mainly GI dependent. Does not act as a regulator of CDF1 transcription. The interactions of ADO1/ZTL and ADO2 with ADO3 prevent its interaction with CDF1. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
CDF1 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CDF4 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

TOC1 -- [Más et al., 2003][Baudry et al., 2010] -- [View TAIR record]

CDF3 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CO -- [Fornara et al., 2009][Song et al., 2014][Mizoguchi et al., 2005][Imaizumi et al., 2005][Sawa et al., 2007][Song et al., 2012] -- [View TAIR record]

CDF2 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CDF5 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

Upstream actors

Protein-protein interactions

CDF5 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

TOE1, RAP2.7 -- [Zhang et al., 2015] -- [View TAIR record]

CDF4 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CDF3 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CO -- [Fornara et al., 2009][Song et al., 2014][Mizoguchi et al., 2005][Imaizumi et al., 2005][Sawa et al., 2007][Song et al., 2012] -- [View TAIR record]

CDF2 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CDF1 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]


GI -- [Fornara et al., 2009][Song et al., 2014][Sawa et al., 2007] -- [View TAIR record]

LKP2 -- [Takase et al., 2011] -- [View TAIR record]

FKF1, ADO3 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins