Detailed gene information

Genes [306]




CSTF64
CLEAVAGE STIMULATING FACTOR 64
TAIR: AT1G71800
UNIPROT: Q9M9G6
NOWOMICS: View List

Publications

Yao Y et al., 2002, J. Exp. Bot.
Herr A J et al., 2006, Proc. Natl. Acad. Sci. U.S.A.
Liu F et al., 2010, Science

Appears in the following schemes

Vernalization
General processes & autonomous pathway

Protein function

Encodes a RNA binding protein that mediates the 3-end processing of mRNA.

Phenotype

Remarks:
CSTF64 is involved in the 3 -end processing of the antisense FLC mRNA. cstf64 single mutant has increased FLC expression levels. [Liu et al., 2010]

Function:
One of the multiple factors required for polyadenylation and 3 -end cleavage of pre-mRNAs (By similarity). This subunit is directly involved in the binding to pre-mRNAs, especially on the 3 non-coding region (PubMed:12379796). Required for the targeted 3 processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (PubMed:17008405, PubMed:19965720). [Data from UniProt]

Regulators, targets and interactors

Downstream actors

causality
FLC, AGL25, FLF -- [Liu et al., 2010] -- [View TAIR record]



Upstream actors


Protein-protein interactions


CSTF64 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins