Protein function
Encodes a histone methyltransferase involved in the di- and tri-methylation of histone H3-lysine 36.
Phenotype
Remarks: efs single mutant has reduced
FLC expression levels.
[Kim et al., 2005] Single mutant: efs single mutant is late flowering under both SD and LD conditions.
[Kim et al., 2005][Soppe et al., 1999] Function:Histone methyltransferase involved in di and tri-methylation of Lys-36 of histone H3 (H3K36me2 and H3K36me3). Binds to H3 already mono- or di-methylated on Lys-4 (H3K4me1 or H3K4me2), but not to H3K4me3. H3K4me and H3K36me represent specific tags for epigenetic transcriptional activation. Regulates positively FLC transcription to prevent early flowering transition. Required for flowering transition in response to vernalization and for the maintenance of FLC expression in late embryos, but dispensable for the initial reactivation in early embryos during reprogramming. Seems also to modulate several traits including floral organ size, root size and dormancy. Promotes apical dominance (PubMed:16299497, PubMed:10518493, PubMed:16258034, PubMed:18070919, PubMed:19915673, PubMed:20711170). Directly involved in the tri-methylation of Lys-36 of histone H3 (H3K36me3) at LAZ5 chromatin to maintain a transcriptionally active state of LAZ5, a TIR-NB-LRR protein involved in innate immunity (PubMed:20949080).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FT --
[Shafiq et al., 2014][Bu et al., 2014] --
[View TAIR record] Upstream actors
Protein-protein interactions