Protein function
Encodes a homebox transcription factor that plays a central roles in different developmental processes, including flowering.
Phenotype
Overexpressor: Ectopic expression of
WUS is sufficient to convert cells in organ promordia.
[Schoof et al., 2000][Gallois et al., 2004] Single mutant: In
wus single mutant, the mesitem is quickly consumed, which leads to the development of inclomplete flowers.
[Mayer et al., 1998] Remarks: The WUSCHEL protein plays a central role in the maintenance of stem cell populations in shoot and floral meristems.
[Laux et al., 1996][Mayer et al., 1998] Function:Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development. Binds directly to the 5 -TTAAT[GC][GC]-3 DNA sequence in the regulatory sequence of AG and activates its expression directly. Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain. Participates in the promotion of vegetative to embryonic transition. Required to repress LEC1 expression.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality AG --
[Lenhard et al., 2001][Lohmann et al., 2001] --
[View TAIR record] Upstream actors
Protein-protein interactions