Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Schultz T F et al., 2001, Plant Cell
Yasuhara M et al., 2004, J. Exp. Bot.
Fornara F et al., 2009, Dev. Cell
Baudry A et al., 2010, Plant Cell
Takase T et al., 2011, Plant J.
Ito S et al., 2012, Mol Plant

Appears in the following schemes

Circadian clock overview
Photoperiod pathway

Protein function

Encodes a component of the E3 ubiquitin ligase complex involved in the regulation of blue-light dependent circadian cycles.

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Phenotype

Overexpressor:
LKP2 overexpressor is late flowering under LD conditions only. [Takase et al., 2011][Schultz et al., 2001]

Single mutant:
lkp2 single mutant does not display any flowering-time phenotype. [Imaizumi et al., 2005][Takase et al., 2011]

Multiple mutant:
lkp2;ztl multiple mutant is early flowering under both SD and LD conditions as compared to ztl single mutant. [Imaizumi et al., 2005]

Function:
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO2) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5 seem to be substrates of the SCF(ADO2) complex. ADO2 interacts with ADO3 and export it to cytoplasmic speckles, preventing the interaction of ADO3 with CDF1. Ubiquitination of ADO2 is not involved in this recruitment. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
CDF1 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

CDF4 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

CDF3 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

TOC1 -- [Más et al., 2003][Baudry et al., 2010] -- [View TAIR record]

CDF2 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

CDF5 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

Upstream actors

Protein-protein interactions

FKF1, ADO3 -- [Takase et al., 2011] -- [View TAIR record]

TOE1, RAP2.7 -- [Zhang et al., 2015] -- [View TAIR record]


GI -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

CDF5 -- [Imaizumi et al., 2005] -- [View TAIR record]

CDF4 -- [Imaizumi et al., 2005] -- [View TAIR record]

CDF3 -- [Imaizumi et al., 2005] -- [View TAIR record]

CDF2 -- [Imaizumi et al., 2005] -- [View TAIR record]

CDF1 -- [Imaizumi et al., 2005] -- [View TAIR record]

LKP2 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins