Protein function
Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
Phenotype
Overexpressor: MED18 overexpressor is early flowering. No information about photoperiod.
[Zheng et al., 2013] Remarks: med18 single mutant has increased
FLC expression levels.
[Zheng et al., 2013] Single mutant: med18 single mutant is late flowering under both SD and LD conditions.
[Zheng et al., 2013][Lai et al., 2014] Function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions