Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
overexpressor is early flowering. No information about photoperiod. [Zheng et al., 2013] Remarks: med18
single mutant has increased FLC
expression levels. [Zheng et al., 2013] Single mutant: med18
single mutant is late flowering under both SD and LD conditions. [Zheng et al., 2013][Lai et al., 2014] Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. [Data from UniProt]
Regulators, targets and interactors