Protein function
Encodes a component of the E3 ubiquitin ligase complex.
Phenotype
Single mutant: cop1 single mutant is late flowering under both SD and LD conditions. ( However, McNellis et al. (1994) suggested a phenotype restricted to SD conditions.)
[Jang et al., 2008] Remarks: Overexpression of
COP1 in phloem companion cells of
cop1-4 mutant partially restored the wild-type flowering time.
[Jang et al., 2008] Remarks:The phenotype of the
cop1 mutant is largely dependent on
CO expression, since COP1 is involved in the degradation of CO protein during the night.
[Jang et al., 2008] Function:E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality GI --
[Yu et al., 2008] --
[View TAIR record]CO --
[Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] --
[View TAIR record] Upstream actors
causality CRY1 --
[Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] --
[View TAIR record]CRY2 --
[Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] --
[View TAIR record] Protein-protein interactions
SPA4 --
[Hoecker et al., 2001][Saijo et al., 2003][Laubinger et al., 2004][Zhu et al., 2008] --
[View TAIR record]SPA1 --
[Hoecker et al., 2001][Saijo et al., 2003][Laubinger et al., 2004][Zhu et al., 2008] --
[View TAIR record]SPA3 --
[Hoecker et al., 2001][Saijo et al., 2003][Laubinger et al., 2004][Zhu et al., 2008] --
[View TAIR record]SPA2 --
[Hoecker et al., 2001][Saijo et al., 2003][Laubinger et al., 2004][Zhu et al., 2008] --
[View TAIR record]CO --
[Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] --
[View TAIR record] CRY2 --
[Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] --
[View TAIR record]ELF3 --
[Yu et al., 2008] --
[View TAIR record]CRY1 --
[Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] --
[View TAIR record]BBX19 --
[Wang et al., 2015] --
[View TAIR record]CUL4 --
[Zhu et al., 2015][Chen et al., 2010] --
[View TAIR record]