Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Doyle M R et al., 2002, Nature
Kikis E A et al., 2005, Plant J.
McWatters H G et al., 2007, Plant Physiol.
Kim Y et al., 2013, Cell Rep

Appears in the following schemes

Temperature pathway
Circadian clock overview
Photoperiod pathway

Protein function

Encodes a transcription factor involved in the regulation of the circadian clock.

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Phenotype

Overexpressor:
ELF4 overexpressor is late flowering under LD conditions only. [McWatters et al., 2007]

Single mutant:
elf4 single mutant is late flowering under both SD and LD conditions. ( The phenotype is stronger under SD than LD conditions.) [Doyle et al., 2002][McWatters et al., 2007]

Remarks:
ELF4 protein interacts with GIGANTEA to sequester it from the nucleoplasm. [Kim et al., 2013]

Function:
Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. Increases ELF3 nuclear distribution and localization in nuclear bodies. Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression. Mediates both entrainment to an environmental cycle and circadian rhythm sustainability under constant conditions. Controls flowering time. Necessary for light-induced expression of both CCA1 and LHY. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
GI -- [Kim et al., 2013][Helfer et al., 2011][Kolmos et al., 2007] -- [View TAIR record]

ELF3 -- [Helfer et al., 2011] -- [View TAIR record]

LUX, PCL1 -- [Helfer et al., 2011] -- [View TAIR record]

PIF5, PIL6 -- [Dixon et al., 2011][Nozue et al., 2007][Thines et al., 2010][Thines et al., 2014][Mizuno et al., 2014][Yamashino et al., 2003] -- [View TAIR record]

BOA -- [Helfer et al., 2011] -- [View TAIR record]

PIF4 -- [Dixon et al., 2011][Nozue et al., 2007][Nusinow et al., 2011][Thines et al., 2010][Thines et al., 2014][Mizuno et al., 2014][Yamashino et al., 2003] -- [View TAIR record]

ELF4 -- [Helfer et al., 2011] -- [View TAIR record]

Upstream actors

causality
ELF3 -- [Helfer et al., 2011] -- [View TAIR record]

LUX, PCL1 -- [Helfer et al., 2011][Nusinow et al., 2011] -- [View TAIR record]

BOA -- [Helfer et al., 2011] -- [View TAIR record]

ELF4 -- [Helfer et al., 2011] -- [View TAIR record]

RVE8 -- [Hsu et al., 2013] -- [View TAIR record]

Protein-protein interactions

GI -- [Kim et al., 2013][Helfer et al., 2011][Kolmos et al., 2007] -- [View TAIR record]


LUX, PCL1 -- [Helfer et al., 2011][Nusinow et al., 2011] -- [View TAIR record]

ELF4 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins