Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Huq E et al., 2002, EMBO J.
Koini M A et al., 2009, Curr. Biol.
Franklin K A et al., 2011, Proc. Natl. Acad. Sci. U.S.A.
Kumar S V et al., 2012, Nature
Oh E et al., 2012, Nat. Cell Biol.
Nomoto Y et al., 2012, Plant Cell Physiol.
Thines B C et al., 2014, J. Exp. Bot.

Appears in the following schemes

Overview
Temperature pathway
Hormone pathway
Gibberellin metabolism
Circadian clock overview
Photoperiod pathway

Protein function

Encodes a bHLH transcription factor.

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Phenotype

Overexpressor:
PIF4 overexpressor is early flowering under both SD and LD conditions. [Kumar et al., 2012]

Single mutant:
pif4 single mutant is not or only slightly late flowering under SD conditions at 22C but very late flowering at 27C. pif4 single mutant does not show any flowering-time phenotype under LD conditions at 22C, but no data available at 27C. [Koini et al., 2009][Kumar et al., 2012][Thines et al., 2014]

Multiple mutant:
pif4;pif5 multiple mutant is late flowering under 12h-light-12h-dark photoperiod at any temperature, even though the phenotype is enhanced at high temperatures. (No data under SD or LD conditions.) [Thines et al., 2014]

Remarks:
PIF4 is involved in temperature-dependent flowering induction through its binding to the FT promoter at high temperatures. [Kumar et al., 2012][Thines et al., 2014]

Function:
Transcription factor acting negatively in the phytochrome B signaling pathway. May regulate the expression of a subset of genes involved in cell expansion by binding to the G-box motif. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
FT -- [Kumar et al., 2012][Seaton et al., 2015] -- [View TAIR record]

Upstream actors

causality
GAI, RGA2 -- [de Lucas et al., 2008] -- [View TAIR record]

RGL2 -- [de Lucas et al., 2008] -- [View TAIR record]

ELF4 -- [Dixon et al., 2011][Nozue et al., 2007][Nusinow et al., 2011][Thines et al., 2010][Thines et al., 2014][Mizuno et al., 2014][Yamashino et al., 2003] -- [View TAIR record]

RGL1 -- [de Lucas et al., 2008] -- [View TAIR record]

PHYB -- [Sakuraba et al., 2014][Huq et al., 2002][Khanna et al., 2004][Lorrain et al., 2008] -- [View TAIR record]

LUX, PCL1 -- [Dixon et al., 2011][Nozue et al., 2007][Nusinow et al., 2011][Thines et al., 2010][Thines et al., 2014][Mizuno et al., 2014][Yamashino et al., 2003] -- [View TAIR record]

RGA1 -- [de Lucas et al., 2008] -- [View TAIR record]

RGL3 -- [de Lucas et al., 2008] -- [View TAIR record]

ELF3 -- [Dixon et al., 2011][Nozue et al., 2007][Nusinow et al., 2011][Thines et al., 2010][Thines et al., 2014][Mizuno et al., 2014][Raschke et al., 2015][Yamashino et al., 2003] -- [View TAIR record]

Protein-protein interactions

GAI, RGA2 -- [de Lucas et al., 2008] -- [View TAIR record]

RGL1 -- [de Lucas et al., 2008] -- [View TAIR record]

RGA1 -- [de Lucas et al., 2008] -- [View TAIR record]

PHYB -- [Sakuraba et al., 2014][Huq et al., 2002][Khanna et al., 2004][Lorrain et al., 2008] -- [View TAIR record]

RGL2 -- [de Lucas et al., 2008] -- [View TAIR record]

FCA -- [Lee et al., 2014] -- [View TAIR record]

RGL3 -- [de Lucas et al., 2008] -- [View TAIR record]

PIF4 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins