Detailed gene information

Genes [306]




SPA1
SPA1-RELATED 1
TAIR: AT2G46340
UNIPROT: Q9SYX2
NOWOMICS: View List

Publications

Hoecker U et al., 1998, Plant Cell
Hoecker U et al., 1999, Science
Hoecker U et al., 2001, J. Biol. Chem.
Seo H S et al., 2003, Nature
Saijo Y et al., 2003, Genes Dev.
Ishikawa M et al., 2006, Plant J.
Laubinger S et al., 2006, Development
Zhu D et al., 2008, Plant Cell
Saijo Y et al., 2008, Mol. Cell
Zuo Z et al., 2011, Curr. Biol.
Liu B et al., 2011, Genes Dev.

Appears in the following schemes

Photoperiod pathway
Time-course regulation of photoperiodic pathway

Protein function

Encodes a subunit of the COP1/SPA E3 ubiquitin-protein ligase complex.

Phenotype

Single mutant:
spa1 single mutant is early flowering under SD conditions only. [Chen et al., 2010][Laubinger et al., 2006][Ishikawa et al., 2006][Zuo et al., 2011]

Multiple mutant:
spa1, spa3, and spa4 mutations has additive effects and lead to an early-flowering phenotype under both SD and LD conditions. ( The phenotype is stronger under SD conditions. The early flowering-time phenotype of the multiple mutant requires spa1 mutation, since spa2;spa3;spa4 multiple mutant shows only minor flowering time alterations.) [Laubinger et al., 2006][Laubinger et al., 2006][Balcerowicz et al., 2011]

Function:
Controls normal photoperiodic flowering and regulates circadian rhythms. Required for suppression of photomorphogenesis in dark-grown seedlings and for normal elongation growth of adult plants. Integral component of the COP1/SPA E3 ubiquitin-protein ligase complex. Involved in HY5, HFR1, LAF1 and CO degradation. [Data from UniProt]

Regulators, targets and interactors

Downstream actors

causality
CO -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]



Upstream actors

causality
CRY1 -- [Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] -- [View TAIR record]

CRY2 -- [Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] -- [View TAIR record]



Protein-protein interactions

CRY2 -- [Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] -- [View TAIR record]

COP1 -- [Hoecker et al., 2001][Saijo et al., 2003][Laubinger et al., 2004][Zhu et al., 2008] -- [View TAIR record]

CRY1 -- [Zuo et al., 2011][Li et al., 2011][Liu et al., 2011][Lian et al., 2011] -- [View TAIR record]

CUL4 -- [Zhu et al., 2015][Chen et al., 2010] -- [View TAIR record]



SPA1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins