Protein function
Encodes a subunit of the PRC2 complex, which is involed in histone methylation.
Phenotype
Remarks: FIE1 encodes a subunit of the PRC2 complex, which is involved in the negative regulation of
FLC expression. FIE1 is also involved in
FT repression. Co-suppression of
FIE expression leads to increased
FLC expression levels.
[Jiang et al., 2008] Single mutant: Conflicting results.
fie1 single mutant flowers very early under LD conditions. However, RNAi downregulation of
FIE1 expression leads to a late-flowering phenotype. ( No data under SD conditions.)
[Wood et al., 2006][Jiang et al., 2008] Function:Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. Probably also involved in floral repression mechanism established during early plant development. Regulates the anteroposterior organization of the endosperm. Interacts with the promoter and repress the transcription of genes such as PHE1, that are paternally active and maternally silenced.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality AG --
[Goodrich et al., 1997][Kinoshita et al., 2001][Chen et al., 1997][Hennig et al., 2003] --
[View TAIR record]AGL19 --
[Schönrock et al., 2006] --
[View TAIR record] Upstream actors
Protein-protein interactions
MEA, FIS1 --
[Spillane et al., 2000][Yadegari et al., 2000] --
[View TAIR record] VIL1, VRN5 --
[De Lucia et al., 2008] --
[View TAIR record]VRN2 --
[Wood et al., 2006] --
[View TAIR record]