Protein function
Encodes a component of the SWR1 complex that regulate gene expression through H2A & H2A.F/Z remodelling.
Phenotype
Remarks: esd1 single mutant has reduced
FLC expression levels.
[Deal et al., 2005][Choi et al., 2005] Single mutant: esd1 single mutant is early flowering under both SD and LD conditions.
[Deal et al., 2005][Martü¾™†”¼n-Trillo et al., 2006][Kumar et al., 2010][Choi et al., 2005] Remarks: ESD1 is part of the SWR1 complex, which is involved in the deposition of H2A.Z at multiple loci, including
FLC.
[Deal et al., 2007] Overexpressor: Overexpression of
ESD1 does not lead to any flowering-time phenotype.
[Deal et al., 2005] Function:Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Binds to the promoter region of FLC chromatin. Required for the activation of FLC and FLC/MAF genes expression to levels that inhibit flowering, through both histone H3 and H4 acetylation and methylation mechanisms. Involved in several developmental processes including organization of plant organs, leaves formation, flowering time repression, and fertility. Modulates photoperiod-dependent epidermal leaves cell development; promotes cell division in long days, and cell expansion/division in short days. May be involved in the regulation of pathogenesis-related proteins (PRs).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions
SEF, SWC6 --
[Choi et al., 2007] --
[View TAIR record] PIE1 --
[Choi et al., 2007] --
[View TAIR record]