Detailed gene information

Genes [306]

TAIR: AT3G43920


Gasciolli V et al., 2005, Curr. Biol.
Henderson I R et al., 2006, Nat. Genet.
Schmitz R J et al., 2007, Genetics
Nagano H et al., 2014, Nucleic Acids Res.

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes a Dicer homolog involved in microRNA processing.


dcl1;dcl3 double mutants has lower microRNA expression levels, including miR156 microRNA. [Gasciolli et al., 2005]

Multiple mutant:
dcl3;dcl4 multiple mutant is late flowering under both SD or LD conditions. [Gasciolli et al., 2005]

Multiple mutant:
The dcl1;dcl3 double mutant is late flowering under both SD and LD conditions. (The late flowering time is suppresed by vernalization in the Col FRI background.) [Schmitz et al., 2007]

Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Involved in the processing of repeat-associated small interfering RNAs (ra-siRNAs, derived from heterochromatin and DNA repeats such as transposons) by cleaving small dsRNAs into 24 nucleotide ra-siRNAs. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the cabbage leaf curl virus (CaLCuV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV) that inactivates DCL3 function in RNA silencing. Acts redundantly with DICER-LIKE 1 (DCL1) to promote flowering via repression of FLOWERING LOCUS C (FLC). Does not seem to be involved in microRNAs (miRNAs) processing. [Data from UniProt]

Regulators, targets and interactors

Downstream actors

Upstream actors

Protein-protein interactions

DCL3 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins