Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
overexpressor does not display any flowering-time phenotype. [Imura et al., 2012] Remarks: med12
single mutant has increased FLC
expression levels. [Gillmor et al., 2014] Single mutant: med12
single mutant is late flowering under LD conditions only. [Imura et al., 2012] Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Flowering regulator which suppresses FLC expression, promotes FT and TSF expression and up-regulates SOC1 and FUL mainly in an FT-dependent manner under long-day conditions. Involved in diverse developmental aspects through gene regulation and modulation of the auxin response. Acts closely together with MAB13. Involved in the regulation of embryo patterning and cotyledon organogenesis by transiently repressing a transcriptional program that interferes with this process. [Data from UniProt]
Regulators, targets and interactors