Protein function
Encodes an homeodomain-containing protein involved in the stabilization of the R-loop at the
FLC locus.
Phenotype
Single mutant: atndx single mutant is late flowering under LD conditions. ( No data under SD conditions.)
[Sun et al., 2013] Remarks: ATNDX was originally identified in a screen for modification of
COOLAIR (antisense
FLC transcript) expression.
atndx single mutant shows reduced
COOLAIR expression. ATNDX is involved in the stablilization of the R-loop that represses the transcription of
COOLAIR.
[Sun et al., 2013] Function:Regulates COOLAIR, a set of antisense transcripts originating from the 3 end of FLOWERING LOCUS C (FLC). Associates with single-stranded DNA that is part of an RNA-DNA hybrid, or R-loop, that covers the COOLAIR promoter. R-loop stabilization mediated by NDX inhibits COOLAIR transcription, which in turn modifies FLC expression.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions