Detailed gene information

Genes [306]




MED16, SFR6
MEDIATOR 16, SENSITIVE TO FREEZING 6
TAIR: AT4G04920
UNIPROT: F4JGZ1
NOWOMICS: View List

Publications

Knight H et al., 1999, Plant Cell
Boyce J M et al., 2003, Plant J.
Knight H et al., 2008, Plant Physiol.
Knight H et al., 2009, Plant J.
Wathugala D L et al., 2012, New Phytol.
Zhang X et al., 2013, Plant J.
Hemsley P A et al., 2014, Plant Cell

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.

Phenotype

Single mutant:
med16 single mutant is late flowering under LD conditions. ( No data available under SD conditions.) [Yang et al., 2014][Knight et al., 2008]

Remarks:
MED16 regulates the expression of the circadian clock components CCA1, GI and TOC1. [Knight et al., 2008]

Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the regulation of the circadian clock, in the control of flowering time, in freezing- and osmotic-stress tolerance and in both salicylic acid- and jasmonate-mediated defense gene expression. [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


MED16, SFR6 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins