Encodes a component of the Mediator complex, which is involved in the transcriptional regulation of RNA-polymerase II-dependent genes.
Single mutant: med16
single mutant is late flowering under LD conditions. ( No data available under SD conditions.) [Yang et al., 2014][Knight et al., 2008] Remarks:
MED16 regulates the expression of the circadian clock components CCA1
. [Knight et al., 2008] Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the regulation of the circadian clock, in the control of flowering time, in freezing- and osmotic-stress tolerance and in both salicylic acid- and jasmonate-mediated defense gene expression. [Data from UniProt]
Regulators, targets and interactors