Protein function
Encodes a subunit of the FACT complex, a chromatin remodelling complex involved in the reorganization of nucleosomes.
Phenotype
Single mutant: spt16 single mutant is early flowering under both SD and LD conditions in terms of days to flowering. However,
spt16 single mutant produces more leaves than wild-type plants under SD conditions.
[Lolas et al., 2010] Remarks: ssrp1 single mutant displays pleiotropic defects and has reduced
FLC expression levels.
[Lolas et al., 2010] Function:Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FLC, AGL25, FLF --
[Lolas et al., 2010] --
[View TAIR record] Upstream actors
Protein-protein interactions