Encodes a protease involved in the SUMO pathway.
Single mutant: esd4
single mutant is early flowering under both SD and LD conditions. ( Analysis performed in the Ler Background). [Reeves et al., 2002][Murtas et al., 2003][Villajuana-Bonequi et al., 2014] Overexpressor:
Overexpression of ESD4
does not lead to any flowering-time phenotype. [Murtas et al., 2003] Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Acts predominantly as an isopeptidase, cleaving SUMO-conjugated proteins better than SUMO peptides. Plays an important role in the control of flowering time. [Data from UniProt]
Regulators, targets and interactors