Detailed gene information

Genes [306]




SKB1, PRMT5
SHK1 BINDING PROTEIN 1 , PROTEIN ARGININE METHYLTRANSFERASE 5
TAIR: AT4G31120
UNIPROT: Q8GWT4
NOWOMICS: View List

Publications

Wang X et al., 2007, EMBO J.
Pei Y et al., 2007, Plant Physiol.
Schmitz R J et al., 2008, Proc. Natl. Acad. Sci. U.S.A.
Sanchez S E et al., 2010, Nature
Zhang Z et al., 2011, Plant Cell
Fu Y et al., 2013, Plant Cell
Fan H et al., 2014, Plant J.

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes an arginine methyltransferase.

Phenotype

Overexpressor:
SKB1 overexpressor is early flowering under LD conditions. ( No data available under SD conditions.) [Wang et al., 2007]

Remarks:
skb1 single mutant has increased FLC expression levels. [Wang et al., 2007][Schmitz et al., 2008]

Single mutant:
skb1 single mutant is late flowering under both SD and LD conditions. [Wang et al., 2007][Pei et al., 2007][Schmitz et al., 2008][Schmitz et al., 2008][Zhang et al., 2011]

Function:
Methylates arginine residues of myelin basic protein (MBP) in vitro. Methylates symmetrically histone H4 of the FLC chromatin to form H4R3me2s, which in turn suppresses FLC expression to induce flowering. Regulates alternative splicing by methylating spliceosomal proteins. Involved in the post-transcriptional regulation of the circadian clock. [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


SKB1, PRMT5 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins