Protein function
Encodes a MADS-box transcription factor.
Phenotype
Overexpressor: FLC overexpressor is late flowering under both SD and LD conditions.
[Michaels et al., 1999][Sheldon et al., 1999] Single mutant: flc single mutant is early flowering under both SD and LD conditions, especially in the Col
FRI background and other winter-accessions.
[Michaels et al., 1999][Michaels et al., 2001][Sheldon et al., 1999] Remarks: Antisense (
COOLAIR) and alternative transcripts (
COLDAIR) of
FLC are involved in its regulation and are evolutionary-conserved.
[Heo et al., 2011][Liu et al., 2010][Swiezewski et al., 2009] Remarks: FLC and SVP have a subset of common targets: the FLC-SVP duplex binds to multiple flowering time genes, including gibberelin-related factors. However, FLC and SVP also have their own specific targets.
[Mateos et al., 2015] Remarks: FLC interacts with SVP and binds to the promoter of
FT and
SOC1 to repress their expression.
[Li et al., 2008][Hepworth et al., 2002] Function:Putative transcription factor that seems to play a central role in the regulation of flowering time in the late-flowering phenotype by interacting with FRIGIDA , the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 .
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FT --
[Li et al., 2008][Deng et al., 2011][Lee et al., 2007][Searle et al., 2006][Helliwell et al., 2006][Jang et al., 2009][Tao et al., 2012][Gregis et al., 2013][Mateos et al., 2015] --
[View TAIR record]SEP3 --
[Deng et al., 2011][Mateos et al., 2015] --
[View TAIR record]TOE3 --
[Deng et al., 2011][Mateos et al., 2015] --
[View TAIR record]FLC, AGL25, FLF --
[Csorba et al., 2014][Heo et al., 2011] --
[View TAIR record]SOC1, AGL20 --
[Li et al., 2008][Deng et al., 2011][Searle et al., 2006][Helliwell et al., 2006][Tao et al., 2012][Gregis et al., 2013][Mateos et al., 2015][Hepworth et al., 2002] --
[View TAIR record]SMZ --
[Deng et al., 2011][Mateos et al., 2015] --
[View TAIR record]TOE1, RAP2.7 --
[Mateos et al., 2015] --
[View TAIR record]FD --
[Deng et al., 2011][Searle et al., 2006] --
[View TAIR record]AP3 --
[Deng et al., 2011][Mateos et al., 2015] --
[View TAIR record]SPL15 --
[Deng et al., 2011][Mateos et al., 2015] --
[View TAIR record] Upstream actors
causality YAF9A, TAF14B, GAS41 --
[Zacharaki et al., 2012] --
[View TAIR record]VOZ1 --
[Yasui et al., 2014][Yasui et al., 2012][Celesnik et al., 2013] --
[View TAIR record]CSTF64 --
[Liu et al., 2010] --
[View TAIR record]ELF8, VIP6 --
[He et al., 2004] --
[View TAIR record]TFL2, LHP1 --
[Sung et al., 2006] --
[View TAIR record]ICE1, SCRM --
[Lee et al., 2015] --
[View TAIR record]BAF60, CHC1 --
[Jégu et al., 2014][Sacharowski et al., 2015] --
[View TAIR record]ATX2 --
[Pien et al., 2008][Shafiq et al., 2014][Berr et al., 2015] --
[View TAIR record]PIE1 --
[Noh et al., 2003] --
[View TAIR record]LIF2 --
[Latrasse et al., 2011] --
[View TAIR record]FCA --
[Marquardt et al., 2014][Liu et al., 2010] --
[View TAIR record]FLD, RSI1 --
[Jiang et al., 2009] --
[View TAIR record]FRI --
[Johanson et al., 2000] --
[View TAIR record]UBC2 --
[Cao et al., 2008][Gu et al., 2009] --
[View TAIR record]CSTF77 --
[Liu et al., 2010] --
[View TAIR record]ELF7 --
[He et al., 2004] --
[View TAIR record]CUL4 --
[Pazhouhandeh et al., 2011] --
[View TAIR record]FLC, AGL25, FLF --
[Csorba et al., 2014][Heo et al., 2011] --
[View TAIR record]DET1, FUS2 --
[Kang et al., 2015] --
[View TAIR record]ATX1, SDG27 --
[Pien et al., 2008][Shafiq et al., 2014][Berr et al., 2015] --
[View TAIR record]UGT87A2 --
[Wang et al., 2012] --
[View TAIR record]SPT16 --
[Lolas et al., 2010] --
[View TAIR record]HUA2 --
[Doyle et al., 2005][Cheng et al., 2003] --
[View TAIR record]WDR5A --
[Jiang et al., 2009] --
[View TAIR record]FY --
[Liu et al., 2010] --
[View TAIR record]UBC1 --
[Cao et al., 2008][Gu et al., 2009] --
[View TAIR record]SUF4 --
[Choi et al., 2011] --
[View TAIR record]PHP, CDC73 --
[Yu et al., 2010] --
[View TAIR record]VOZ2 --
[Yasui et al., 2014][Yasui et al., 2012][Celesnik et al., 2013] --
[View TAIR record]CDKC;2 --
[Wang et al., 2014] --
[View TAIR record]HDA5 --
[Luo et al., 2015] --
[View TAIR record]CLF, SDG1 --
[Jiang et al., 2008][Lopez-Vernaza et al., 2012] --
[View TAIR record]JMJ15, MEE27 --
[Yang et al., 2012] --
[View TAIR record]SSRP1, HMG, NFD --
[Lolas et al., 2010] --
[View TAIR record]SWP73A --
[Sacharowski et al., 2015] --
[View TAIR record]GASA5 --
[Zhang et al., 2009] --
[View TAIR record]ATXR7, SDG25 --
[Tamada et al., 2009] --
[View TAIR record]FPA --
[Liu et al., 2010] --
[View TAIR record]HUB1 --
[Cao et al., 2008][Gu et al., 2009] --
[View TAIR record]UBP26 --
[Schmitz et al., 2009] --
[View TAIR record] Protein-protein interactions
FLM, MAF1, AGL27 --
[Gu et al., 2013] --
[View TAIR record]SVP --
[Li et al., 2008][Fujiwara et al., 2008][Hu et al., 2014] --
[View TAIR record] MAF3, AGL70 --
[Gu et al., 2013] --
[View TAIR record]MAF4, AGL69 --
[Gu et al., 2013] --
[View TAIR record]