Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Koornneef M et al., 1991, Mol. Gen. Genet.
Putterill J et al., 1993, Mol. Gen. Genet.
Hensel L L et al., 1993, Plant Cell
Putterill J et al., 1995, Cell
Simon R et al., 1996, Nature
Samach A et al., 2000, Science
Onouchi H et al., 2000, Plant Cell
Surez-Lpez P et al., 2001, Nature
Valverde F et al., 2004, Science
An H et al., 2004, Development
Yoo S K et al., 2005, Plant Physiol.
Wenkel S et al., 2006, Plant Cell

Appears in the following schemes

Overview
Circadian clock overview
Photoperiod pathway
Time-course regulation of photoperiodic pathway

Protein function

Encodes a zinc finger transcription factor involved in the regulation of FT expression.

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Phenotype

Overexpressor:
CO overexpressor is early flowering under both SD and LD conditions [Simon et al., 1996][Samach et al., 2000][Suü¾Œ–”¼rez-Lü¾Œ¶˜¼pez et al., 2001][Onouchi et al., 2000]

Single mutant:
co single mutant is late flowering under LD conditions only. [Simon et al., 1996][Koornneef et al., 1991][Samach et al., 2000][Putterill et al., 1995]

Function:
Putative transcription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering. Plays a role in the regulation of flowering time by acting on SUPPRESSOR OF OVEREXPRESSION OF CO1 , TERMINAL FLOWER 1 and FLOWERING LOCUS T . Also regulates P5CS2 and ACS10 (involved in proline and ethylene biosynthesis, respectively). [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
FT -- [Kumimoto et al., 2008][Endo et al., 2013][Yamaguchi et al., 2005][Yoo et al., 2005][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010][Song et al., 2012][Tiwari et al., 2010][Endo et al., 2014][Song et al., 2008][Samach et al., 2000][Kardailsky et al., 1999][Kobayashi et al., 1999] -- [View TAIR record]

GBSS -- [Ortiz-Marchena et al., 2014] -- [View TAIR record]

TSF -- [Yamaguchi et al., 2005][Yoo et al., 2005][Ben-Naim et al., 2006][Tiwari et al., 2010][Samach et al., 2000][Kardailsky et al., 1999][Kobayashi et al., 1999] -- [View TAIR record]

AGL17 -- [Han et al., 2008] -- [View TAIR record]

Upstream actors

causality
SPA4 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

PFT1, MED25 -- [Cerdn et al., 2003][Wollenberg et al., 2008][Iigo et al., 2012] -- [View TAIR record]

FBH2 -- [Ito et al., 2012] -- [View TAIR record]

CDF1 -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

RUP2, EFO2 -- [Wang et al., 2011] -- [View TAIR record]

CDF4 -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

ESD6, HOS1 -- [Cerdn et al., 2003][Endo et al., 2013][Jung et al., 2012][Lzaro et al., 2012][Lzaro et al., 2015][Valverde et al., 2004][Halliday et al., 2003] -- [View TAIR record]

COP1 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

SPA3 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

FBH1 -- [Ito et al., 2012] -- [View TAIR record]

ZTL -- [Fornara et al., 2009][Song et al., 2014] -- [View TAIR record]

FBH4, AKS3 -- [Ito et al., 2012] -- [View TAIR record]

CDF3 -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

RFI2 -- [Chen et al., 2006] -- [View TAIR record]

DNF -- [Morris et al., 2010][Morris et al., 2010] -- [View TAIR record]

FKF1, ADO3 -- [Fornara et al., 2009][Song et al., 2014][Mizoguchi et al., 2005][Imaizumi et al., 2005][Sawa et al., 2007][Song et al., 2012] -- [View TAIR record]

SPA2 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

MSI1 -- [Steinbach et al., 2014] -- [View TAIR record]

GI -- [Fornara et al., 2009][Song et al., 2014][Mizoguchi et al., 2005][Imaizumi et al., 2005][Sawa et al., 2007][Song et al., 2012] -- [View TAIR record]

FBH3, AKS1, BHLH122 -- [Ito et al., 2012] -- [View TAIR record]

CDF2 -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

LATE -- [Weingartner et al., 2011] -- [View TAIR record]

CDF5 -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

PHYA -- [Valverde et al., 2004] -- [View TAIR record]

SPA1 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

Protein-protein interactions

NF-YC9, HAP5C -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YB9, LEC1 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

GI -- [Song et al., 2014] -- [View TAIR record]

NF-YC3 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC2, HAP5B -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

AS1 -- [Song et al., 2012] -- [View TAIR record]

NF-YB1, HAP3A -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YB5 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC1, HAP5A -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YB10 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YB3, HAP3C -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

TGA4 -- [Song et al., 2008] -- [View TAIR record]

NF-YB2, HAP3B -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YB6, L1L -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC7 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC6 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC5 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]

NF-YC4 -- [Kumimoto et al., 2008][Cai et al., 2007][Wenkel et al., 2006][Ben-Naim et al., 2006][Kumimoto et al., 2010] -- [View TAIR record]


MRG2 -- [Bu et al., 2014] -- [View TAIR record]

FKF1, ADO3 -- [Fornara et al., 2009][Song et al., 2014][Mizoguchi et al., 2005][Imaizumi et al., 2005][Sawa et al., 2007][Song et al., 2012] -- [View TAIR record]

PHL -- [Endo et al., 2013] -- [View TAIR record]

TOE1, RAP2.7 -- [Zhang et al., 2015] -- [View TAIR record]

COP1 -- [Jang et al., 2008][Liu et al., 2008][Laubinger et al., 2006] -- [View TAIR record]

ESD6, HOS1 -- [Cerdn et al., 2003][Endo et al., 2013][Jung et al., 2012][Lzaro et al., 2012][Lzaro et al., 2015][Valverde et al., 2004][Halliday et al., 2003] -- [View TAIR record]

BBX19 -- [Wang et al., 2014] -- [View TAIR record]

ZTL -- [Fornara et al., 2009][Song et al., 2014] -- [View TAIR record]

CO interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins