Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Larsson A S et al., 1998, Genetics
Takada S et al., 2003, Plant Cell
Kotake T et al., 2003, Plant Cell Physiol.
Libault M et al., 2005, Planta
Mylne J S et al., 2006, Proc. Natl. Acad. Sci. U.S.A.
Turck F et al., 2007, PLoS Genet.
Zhang X et al., 2007, Nat. Struct. Mol. Biol.
Rizzardi K et al., 2011, Plant J.
Latrasse D et al., 2011, PLoS ONE

Appears in the following schemes

Time-course regulation of photoperiodic pathway
Mains targets of ABC(E)genes
FLC regulation through protein complexes
General processes & autonomous pathway

Protein function

Encodes a subunit of the PRC1-like complex, which is involved in the maintenance of repressive chromatin states.

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Phenotype

Overexpressor:
LHP1 overexpression has only very little effect on flowering time. [Takada et al., 2003]

Remarks:
lhp1 single mutant has increased FT expression levels and is not able to maintain vernalized state. lhp1 is required for the epigenetic silencing of FLC expression. [Takada et al., 2003][Kotake et al., 2003][Mylne et al., 2006][Sung et al., 2006]

Single mutant:
lhp1 single mutant is early flowering under both SD and LD conditions. [Latrasse et al., 2011][Takada et al., 2003][Kotake et al., 2003][Gaudin et al., 2001][Matsoukas et al., 2013][Larsson et al., 1998]

Function:
Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me) and Lys-27 (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
FLC, AGL25, FLF -- [Sung et al., 2006] -- [View TAIR record]

FT -- [Zhang et al., 2007][Adrian et al., 2010][Turck et al., 2007] -- [View TAIR record]

AP3 -- [Sung et al., 2006] -- [View TAIR record]

AG -- [Sung et al., 2006][Turck et al., 2007][Gaudin et al., 2001] -- [View TAIR record]

SEP3 -- [Liu et al., 2009] -- [View TAIR record]

Upstream actors

Protein-protein interactions

LIF2 -- [Latrasse et al., 2011] -- [View TAIR record]


SVP -- [Liu et al., 2009] -- [View TAIR record]

EMF1 -- [Wang et al., 2014] -- [View TAIR record]

TFL2, LHP1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins