Detailed gene information

Genes [306]




HUA2
ENHANCER OF AG-4 2
TAIR: AT5G23150
UNIPROT: Q9XER9
NOWOMICS: View List

Publications

Chen X et al., 1999, Mol. Cell
Western T L et al., 2002, Development
Cheng Y et al., 2003, Dev. Cell
Doyle M R et al., 2005, Plant J.
Wang Q et al., 2007, Curr. Biol.
Ilk N et al., 2015, New Phytol.

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes a zinc finger protein involved in mRNA processing.

Phenotype

Multiple mutant:
hua1;hua2 multiple mutant shows developmental flower defects. [Chen et al., 1999][Li et al., 2001][Cheng et al., 2003][Western et al., 2002]

Remarks:
hua2 mutation enhances the early-flowering phenotype of the elf4 mutant and largely suppresses the late flowering-time phenotype of Col FRI background. [Doyle et al., 2005]

Overexpressor:
HUA2 overexpressor is late flowering under both SD and LD conditions. [Wang et al., 2007]

Remarks:
hua2 single mutant has reduced FLC expression levels while HUA2 overexpressor has increased FLC expression levels. [Wang et al., 2007]

Single mutant:
hua2 single mutant is early flowering under both SD and LD conditions. [Wang et al., 2007][Doyle et al., 2005][Ilk et al., 2015][Jali et al., 2014]

Remarks:
HUA2 is involved in the control of AGAMOUS mRNA processing. [Cheng et al., 2003]

Function:
Transcription factor that functions as repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP. Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA. Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression (PubMed:10198637, PubMed:12530963, PubMed:15659097). Acts as transcription regulator that controls anthocyanin accumulation (PubMed:25425527). [Data from UniProt]

Regulators, targets and interactors

Downstream actors

causality
AG -- [Cheng et al., 2003][Chen et al., 1999] -- [View TAIR record]

FLM, MAF1, AGL27 -- [Doyle et al., 2005][Cheng et al., 2003] -- [View TAIR record]

FLC, AGL25, FLF -- [Doyle et al., 2005][Cheng et al., 2003] -- [View TAIR record]



Upstream actors


Protein-protein interactions


HUA2 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins