Detailed gene information

Genes [306]




RRP6L2
AtRRP6L2
TAIR: AT5G35910
UNIPROT: A9LLI7
NOWOMICS: View List

Publications

Lange H et al., 2008, Mol. Cell. Biol.
Shin J et al., 2014, PLoS Genet.

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes a putative exoribonuclease H.

Phenotype

Single mutant:
rrp6l1 single mutant is very slightly late flowering under LD conditions. ( No data under SD conditions.). [Shin et al., 2014]

Multiple mutant:
rrp6l1;rrp6l2 multiple mutant is late flowering under both SD and LD conditions. [Shin et al., 2014]

Remarks:
rrp6l1;rrp6l2 multiple mutant has increased FLC expression levels. [Shin et al., 2014]

Function:
Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed:23555312, PubMed:25211139). Involved in association with RRP6L1 in the silencing of the solo LTR locus. Controls levels of non-coding RNAs (ncRNAs) from the solo LTR locus. Seems to function independently of the RNA-mediated gene silencing (RdDM) pathway (PubMed:23555312). Functions redundantly with RRP6L1 in the regulation of FLC locus. Participates in the maintenance of trimethylated Lys-27 (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus. Seems not involved in the exosomal RNA degradation (PubMed:25211139). May be involved in poly(A)-mediated RNA degradation (PubMed:18285452). [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


RRP6L2 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins