Detailed gene information

Genes [306]




VIM3, ORTH1
VARIANT IN METHYLATION 3, ORTHRUS 1
TAIR: AT5G39550
UNIPROT: Q9FKA7
NOWOMICS: View List

Publications

Kraft E et al., 2008, Plant J.
Woo H R et al., 2008, PLoS Genet.
Kim J et al., 2014, Mol Plant
Shook M S et al., 2014, Epigenetics

Appears in the following schemes

General processes & autonomous pathway

Protein function

Encodes an E3 ubiquitin ligase.

Phenotype

Multiple mutant:
vim1;vim2;vim3 multiple mutant is late flowering under LD conditions. ( No data available under SD conditions.) [Woo et al., 2008]

Overexpressor:
VIM3 overexpressor is late flowering under LD conditions. ( No data available under SD conditions.) [Kraft et al., 2008]

Remarks:
Strangely, both vim1;vim2;vim3 multiple mutant and VIM3 overexpressor are late flowering, suggesting that those phenotypes are caused by different mechanisms. [Woo et al., 2008][Kraft et al., 2008]

Remarks:
vim1;vim2;vim3 multiple mutant shows increased FWA expression levels. [Woo et al., 2008]

Function:
E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e.g. UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. [Data from UniProt]

Regulators, targets and interactors

Downstream actors


Upstream actors


Protein-protein interactions


VIM3, ORTH1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins