Protein function
Encodes an E3 ubiquitin ligase.
Phenotype
Multiple mutant: vim1;
vim2;
vim3 multiple mutant is late flowering under LD conditions. ( No data available under SD conditions.)
[Woo et al., 2008] Overexpressor: VIM3 overexpressor is late flowering under LD conditions. ( No data available under SD conditions.)
[Kraft et al., 2008] Remarks: Strangely, both
vim1;
vim2;
vim3 multiple mutant and
VIM3 overexpressor are late flowering, suggesting that those phenotypes are caused by different mechanisms.
[Woo et al., 2008][Kraft et al., 2008] Remarks:vim1;
vim2;
vim3 multiple mutant shows increased
FWA expression levels.
[Woo et al., 2008] Function:E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e.g. UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions