Protein function
Encodes a component of the cap-binding complex (CBC) that binds to the 5-cap of pre-miRNAs.
Phenotype
Remarks: cbp20 single mutant has reduced miRNA levels and increased pri-miRNA levels.
[Kim et al., 2008] Single mutant: cbp20 single mutant is early flowering under LD conditions in Col-0 and Col
FRI backgrounds. (No data available under SD conditions. The whole plant development seems to be delayed.)
[Geraldo et al., 2009][Papp et al., 2004] Remarks: CBP20 is required for FRI activity. Loss of
CBP20 results in reduced mature
FLC mRNA levels and an increase of unspliced
FLC transcripts.
[Geraldo et al., 2009] Function:Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5 cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary miRNA processing. In the CBC complex, CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ABH1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. CBP20 also plays a role in stabilization of ABH1/CBP80 and ABH1/CBP80 localization to the nucleus. Involved in flowering regulation via its interaction with FRIGIDA.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions