Protein function
Encodes a component of the E3 ubiquitin ligase complex.
Phenotype
Remarks: cul4 single mutant has increased
FLC and
FT expression levels.
[Pazhouhandeh et al., 2011] Single mutant: cul4 single mutant is early flowering under SD conditions only.
[Chen et al., 2010] Remarks: CUL4 interacts with COP1 and SPA1, but also MSI4 and DDB1. Together, they interact with the PRC2 complex to repress
FLC and
FT expression.
[Chen et al., 2010][Pazhouhandeh et al., 2011] Function:Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
causality FLC, AGL25, FLF --
[Pazhouhandeh et al., 2011] --
[View TAIR record]FT --
[Pazhouhandeh et al., 2011] --
[View TAIR record] Upstream actors
Protein-protein interactions
SPA4 --
[Zhu et al., 2015][Chen et al., 2010] --
[View TAIR record]COP1 --
[Zhu et al., 2015][Chen et al., 2010] --
[View TAIR record]SPA1 --
[Zhu et al., 2015][Chen et al., 2010] --
[View TAIR record]SPA3 --
[Zhu et al., 2015][Chen et al., 2010] --
[View TAIR record] FVE, MSI4 --
[Pazhouhandeh et al., 2011] --
[View TAIR record]CLF, SDG1 --
[Pazhouhandeh et al., 2011] --
[View TAIR record]