Detailed gene information

Genes [306]

DCL1LHYGA2ox6MRG2CRY2ATPRMT10ATX2STOESD7, TIL1, ABO4NF-YC9, HAP5CPHYACIB4OTS2LWD1, ATAN11UBC1GAI, RGA2GA3OX1TPLCSTF77ARP4AFR2GIPFT1, MED25TEM1, EDF1CIB5CUL3AVOZ1GA2ox2SUF4FRL2RCD1FBH1GA2ox4CPK33GA2ox7FBH3, AKS1, BHLH122ASH2R, TROHTA9SPA4SPL4RRP6L1NF-YC3HUB2MED13, GCT, MAB2VIM1, ORTH2OTS1, ULP1DVIP5LDL1FTVIM2RGL1AT-STUbl4FKF1, ADO3TEM2, RAV2AP1CDF5CSTF64PHLAFR1SDG26, ASHH1FLM, MAF1, AGL27EFS, SDG8GA2ox1TPS1APL, WDY, FEGA2, ATKS1ELF7PRP8, SUS2, EMB33GA3OX2RGA1UBC2EFMELF8, VIP6ABH1, CBP80CPK6FDP, BZIP27PHYBVIL3, VEL2LKP2MIR156GFVE, MSI4GLK1, GPRI1FIO1GRP7, CCR2MED18SVPAGL17CLF, SDG1SUVR5MIR156AELF3ATCMIR172ATOE1, RAP2.7PUB12FLXUGT87A2ATX1, SDG27COP1SPL3FES1CDF4GA2ox3NF-YA4JMJ15, MEE27SRO1AS1HTA8NF-YB1, HAP3ASNZESD6, HOS1ELF4SPL9FBH4, AKS3VOZ2PIF4FPASDG7, ASSH3CKB4HUB1AHL22AGL6SOC1, AGL20BRM, CHR2LRB1SPA1PRR9CCA1RFI2HULK2AKIN10, SNRK1.1MBD9GASA5RGL2MYR2FLKGID1ACOL9FLD, RSI1MIR172CUBP13PIE1LDL2SPL5SPA3BRC1, TCP18VRN1DNFFIE1, FIS3JMJ30TICPHP, CDC73AtBMI1CVIL1, VRN5LWD2ICE1, SCRMSSRP1, HMG, NFDMYB30ARP6, SUF3, ESD1SUS4DCL3ATJ3HDA9JMJ32, JMJD5PUB13LUX, PCL1CDF3REF6, JMJ12UBP26WDR5ALNK2HTA11SMZAGL16INO80AGL18SPL15PIF5, PIL6CKB3LRB2, POB1GID1BHULK3MED12, CCT, CRPFRILIF2LDGA1AtNDXMED16, SFR6CRY1FBH2DET1, FUS2SPT16XAL2, AGL14NF-YB3, HAP3CESD4PHYDFCAVRN2PHYETSFJMJ14, PKDM7B, JMJ4GA2ox8EBSAGL19CAD2, RML1, GSH1AGL24PGI1MOS1GA20ox1FWA, HDG6WRKY34, MSP3ULT1HXK1, GIN2VIP3, SKI8VIL2, VEL1MIR156BSKB1, PRMT5MIR156CATH1CIB1FDAP2MRG1CSP2, GRP2BBX19SHL1, SHLHB16, ATHB16PRR7TFL1ELF6MIR172BSUC9UBP12FTIP1GA20OX3HAM2, HAG5, HAC11FLC, AGL25, FLFMIR156DEMF1MIR156ENF-YA1, HAP2BFYAGL15BAF60, CHC1COFRL1, SUF8RGL3TFL2, LHP1MYR1DCL4HUA2RUP2, EFO2PRR5FPF1MIR156FGID1CPHYCRRP6L2SEF, SWC6RVE2, CIR1VIM3, ORTH1CDF2HLP1ATXR7, SDG25IDD8, NUCGLK2CBP20YAF9A, TAF14B, GAS41CUL4NF-YB2, HAP3BADG1, APS1CIB2LATEPRMT4AEMF2, CYR1GA20ox2PGM1MIR156HZTLVIN3COL5MSI1SRR1PRR3TOE2SIZ1FUL, AGL8HDA5VIP4TOC1LFYFLX4, FLL4BFTCDF1HDA6, RTS1NF-YC4GIS5, EMB2780LNK1HAM1CDKC;2MAF2, AGL31MAF3, AGL70MAF4, AGL69MAF5, AGL68TOE3

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Publications

Imaizumi T et al., 2005, Science
Nakamichi N et al., 2007, Plant Cell Physiol.
Fornara F et al., 2009, Dev. Cell
Takase T et al., 2011, Plant J.
Song Y H et al., 2012, Science
Fornara F et al., 2015, Plant J.

Appears in the following schemes

Photoperiod pathway
Time-course regulation of photoperiodic pathway

Protein function

Encodes a zinc finger transcription factor.

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Phenotype

Overexpressor:
CDF1 overexpressor is late flowering under LD conditions. [Imaizumi et al., 2005]

Multiple mutant:
cdf1;cdf2;cdf3;cdf5 quadruple mutant is early flowering under both SD and LD conditions, with additive effects. ( In this multiple mutant, CDF1 is downregulated by RNAi while other cdf mutants are null mutants.) [Fornara et al., 2009]

Remarks:
GI acts through CDFs to regulate the expression of CO and FT, but CDFs are also involved in the regulation of additional processes which are not related to the control of flowering-time. GI also has CDF-independent functions - e.g. in the circadian clock. [Fornara et al., 2015]

RNA interference:
RNAi down-regulation of CDF1 leads to early flowering under LD conditions. [Imaizumi et al., 2005]

Function:
Transcription factor that binds specifically to a 5 -AA[AG]G-3 consensus core sequence. A flanking TGT sequence contributes to the specificity of binding. Regulates a photoperiodic flowering response. Transcriptional repressor of CONSTANS expression. The DNA-binding ability is not modulated by GIGANTEA but the stability of CDF1 is controlled by the proteasome-dependent pathway. Ubiquitinated by the SCF(ADO3) E3 ubiquitin ligase complex. Binds to the FT promoter in the morning. [Data from UniProt]

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Regulators, targets and interactors

Downstream actors

causality
FT -- [Song et al., 2012] -- [View TAIR record]

CO -- [Fornara et al., 2009][Rosas et al., 2014][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

Upstream actors

causality
GI -- [Fornara et al., 2009][Kim et al., 2007][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

SRR1 -- [Johansson et al., 2014] -- [View TAIR record]

LKP2 -- [Fornara et al., 2009][Kim et al., 2007] -- [View TAIR record]

FKF1, ADO3 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

Protein-protein interactions

LKP2 -- [Imaizumi et al., 2005] -- [View TAIR record]


GI -- [Fornara et al., 2009][Kim et al., 2007][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

FKF1, ADO3 -- [Fornara et al., 2009][Imaizumi et al., 2005][Sawa et al., 2007] -- [View TAIR record]

CDF1 interaction network

Downstream and upstream flowering-related genes

Physical interactions with other flowering-related proteins