Protein function
Encodes a histone deacetylase-complex subunit.
Phenotype
Single mutant: hda6 single mutant is late flowering under both SD and LD conditions.
[Wu et al., 2008][Yu et al., 2011][Luo et al., 2015] Remarks: HDA6 interacts in vivo with FLD.
[Yu et al., 2011] RNA interference: RNAi downregulation of
HDA6 leads to late flowering under both SD and LD conditions. ( Analysis performed in the Ws background.)
[Wu et al., 2008] Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity (PubMed:11340181, PubMed:12486004, PubMed:15037732, PubMed:16648464). Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). Binds to KNAT1, KNAT2, and KNATM chromatin (PubMed:23271976).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions
FLD, RSI1 --
[Yu et al., 2011][Luo et al., 2015] --
[View TAIR record]