Encodes an acetyltransferase mainly involved in the acetylation of histone H4K5.
overexpressor is late flowering under both SD and LD conditions. [Xiao et al., 2013] Multiple mutant: ham1
heterozygous double mutant is early flowering under LD conditions. ( No data under SD conditions.) [Xiao et al., 2013] Remarks: ham1
homozygous double mutant is lethal. [Latrasse et al., 2008] Artificial microRNA:
Artificial microRNA downregulation of both HAM1
leads to early flowering under both SD and LD conditions [Xiao et al., 2013] Function:
Histone acetyltransferase which may be involved in transcriptional activation. Acetylates Lys-5 of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). [Data from UniProt]
Regulators, targets and interactors