Protein function
Encodes a structural core component of a COMPASS-like H3K4 histone methylation complex.
Phenotype
Remarks: ASH2R encodes a structural core component of the COMPASS-like complex, which is involved in the positive regulation of
FLC expression. Thus,
ASH2R overexpression results in increased
FLC expression level.
[Jiang et al., 2011] Single mutant: ash2r homozygous mutant is not viable.
[Jiang et al., 2011] Overexpressor: ASH2R overexpressor is late flowering under LD conditions. ( No data under SD conditions.)
[Jiang et al., 2011] RNA interference: RNAi downregulation of
ASH2R leads to early flowering under LD conditions. ( No data under SD conditions.)
[Jiang et al., 2011] Function:Trithorax-group gene homolog required for early embryogenesis (PubMed:20118203, PubMed:21423667). Required for the expression of FLC and FLC homologs and represses flowering (PubMed:21423667). Required for proper leaf growth and development (PubMed:21423667). Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 Lys-4 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:21423667).
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions
WDR5A --
[Jiang et al., 2011] --
[View TAIR record]